Zofenopril
| CAS No. | 81872-10-8 | Cat. No. | BCP09233 |
| Name | Zofenopril | ||
| Synonyms | Zofenoprilum;SQ 26900;SQ-26900;SQ26900;(4S)-1-[(2S)-3-(Benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)-L-proline; | ||
| Formula | C22H23NO4S2 | M. Wt | 429.56 |
| Description | Zofenopril is a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril is hydrolyzed in vivo into its active form zofenoprilat. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. | ||
| Pathways | Protease/Metabolic Enzyme Hormone Pathay | ||
| Targets | RAAS/ACE | ||
Structure
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