佐芬普利
| CAS号 | 81872-10-8 | 货号 | BCP09233 |
| 中文名 | 佐芬普利 | ||
| 英文名 | Zofenopril | ||
| 中文别名 | |||
| 英文别名 | Zofenoprilum;SQ 26900;SQ-26900;SQ26900;(4S)-1-[(2S)-3-(Benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)-L-proline; | ||
| 分子式 | C22H23NO4S2 | 分子量 | 429.56 |
| 生物活性 | Zofenopril is a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril is hydrolyzed in vivo into its active form zofenoprilat. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. | ||
| 信号通路 | Protease/Metabolic Enzyme Hormone Pathay | ||
| 靶 点 | RAAS/ACE | ||
结构式
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