ML314
| CAS No. | 1448895-09-7 | Cat. No. | BCP09261 |
| Name | ML314 | ||
| Synonyms | ML314;ML-314; | ||
| Formula | C24H28N4O3 | M. Wt | 420.5 |
| Description | ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. IC50 value: 1.9 uM (EC50) [1] Target: NTR1 agonist Medicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR1 (EC50 = 1.9 μM). ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a b | ||
| Pathways | GPCR/G Protein | ||
| Targets | Neurotensin Receptor | ||
Structure
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