埃罗替尼
| CAS号 | 183321-74-6 | 货号 | BCP09267 |
| 中文名 | 埃罗替尼 | ||
| 英文名 | Erlotinib | ||
| 中文别名 | |||
| 英文别名 | NSC 718781; R1415;R 1415;R-1415CP-358,774; CP-358774; CP358774; OSI-774; OSI 774; OSI774; Erlotinib free base; | ||
| 分子式 | C22H23N3O4 | 分子量 | 393.44 |
| 生物活性 | Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. | ||
| 上下游产品 | 183319-69-9（盐酸埃罗替尼） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR | ||
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Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer
购于瀚香生物(Biochempartner)的埃罗替尼(CAS:183321-74-6)被引用 |
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