FLI-06
| CAS No. | 313967-18-9 | Cat. No. | BCP09289 |
| Name | FLI-06 | ||
| Synonyms | FLI06; FLI 06; | ||
| Formula | C25H30N2O5 | M. Wt | 438.52 |
| Description | FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which was accompanied by a tubule-to-sheet morphological transition of the ER. FLI-06 is the first small molecule acting at such an early stage in secretory traffic. Notch signaling has a pivotal role in numerous cell-fate decisions, and its aberrant activity leads to developmental disorders and cancer. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Notch | ||
Structure
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