CGP 57380
| CAS No. | 522629-08-9 | Cat. No. | BCP27993 |
| Name | CGP 57380 | ||
| Synonyms | CGP57380;CGP-57380; | ||
| Formula | C11H9FN6 | M. Wt | 244.23 |
| Description | CGP-57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 μM). MNK1 overexpression was confirmed in both primary GBMs and glioma cell lines. Inhibition of MNK1 activity in GBM cells by the small molecule CGP57380 suppressed eIF4E phosphorylation, proliferation, and colony formation whereas concomitant treatment with CGP57380 and the mTOR inhibitor rapamycin accentuated growth inhibition and cell-cycle arrest. | ||
| Pathways | MAPK Pathway | ||
| Targets | MNK | ||
Structure
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