AK-7

Description	AK-7 treated R6/2 mice performed significantly better than vehicle treated littermates on the accelerating rotarod at 8 and 11 weeks of age. AK-7 at the 10mg/kg dose was also effective in extending the survival of R6/2 mice. Mean survival of placebo treated R6/2 mice was 94.8±5.4, as compared with 109.2± 2.6 in AK-7 treated (10mg/kg) mice; mean survival of treated R6/2 mice was increased by 13.2%. At the 20 mg/kg dose, treatment with AK-7 caused a non-significant trend towards survival extension.
Pathways	Cell Cycle/DNA Damage Epigenetics
Targets	Sirtuin

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