TPT-260

  • Chemical Properties
CAS No. 769856-81-7 Cat. No. BCP09402
Name TPT-260
Synonyms TPU260;TPU 260;TPU-260;TPT260;TPT 260; R55; NSC-55712; NSC55712; NSC 55712;
Formula C8H12N4S3 M. Wt 260.4
  • Biological Activity
Description TPT-260 , also known as R55, is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.
Pathways Others Pathway 
Targets Others 

Structure

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