TPT-260 Dihydrochloride
| CAS No. | 2076-91-7 | Cat. No. | BCP09401 |
| Name | TPT-260 Dihydrochloride | ||
| Synonyms | TPT-260 2HCl;TPU-260 Dihydrochloride; NSC 55712;NSC-55712;NSC55712;TPT 260;TPT260; | ||
| Formula | C8H14Cl2N4S3 | M. Wt | 333.32 |
| Description | TPT-260 2HCl is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP. | ||
| Pathways | Others Pathway | ||
| Targets | Others | ||
Structure
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