Nicorandil
| CAS No. | 65141-46-0 | Cat. No. | BCP09434 |
| Name | Nicorandil | ||
| Synonyms | Nicorandil;Perisalol;Sigmart;Ikorel;Adancor; | ||
| Formula | C8H9N3O4 | M. Wt | 211.17 |
| Description | Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Potassium Channel | ||
Structure
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