Mertansine

CAS No.	139504-50-0	Cat. No.	BCP09450
Name	Mertansine
Synonyms	DM1; DM-1; DM 1; DM1 Compound; Maytansinoid DM 1; Maytansinoid DM1; Maytansinoid DM-1;
Formula	C35H48ClN3O10S	M. Wt	738.29

Description	Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine.
Pathways	Cell Cycle/DNA Damage
Targets	Microtubule

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