TAK960
| CAS号 | 1137868-52-0 | 货号 | BCP09476 |
| 中文名 | TAK960 | ||
| 英文名 | TAK960 | ||
| 中文别名 | |||
| 英文别名 | TAK-960;TAK 960; | ||
| 分子式 | C27H34F3N7O3 | 分子量 | 561.6 |
| 生物活性 | TAK-960 is an orally available PLK1 inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor TAK-960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | PLK | ||
结构式
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