Demeclocycline hydrochloride

CAS No.	64-73-3	Cat. No.	BCP09474
Name	Demeclocycline hydrochloride
Synonyms	Demeclocycline HCl; Detravis; Ledermycin;
Formula	C21H21ClN2O8.ClH	M. Wt	501.32

Description	Demeclocycline Hydrochloride is the hydrochloride salt of demeclocycline, a broad-spectrum, tetracycline derivative exhibiting antimicrobial, aquaretic and chelating activities. In bacteria, demeclocycline binds reversibly to the 30S ribosomal subunit and blocks the binding of aminoacyl-tRNA to the A-site of the mRNA-ribosome complex, resulting in the inhibition of protein synthesis and bacterial cell death. In mammals, this agent interferes with the action of antidiuretic hormone (ADH) at the level of the renal collecting tubule, resulting in aquaresis. In addition, demeclocycline, which like other tetracyclines chelates calcium in bone and exhibits a yellow fluorescence under ultraviolet (UV) light, may be used as a fluorescent bone-labeling agent in bone histomorphometry.
Pathways	Microbiology/Virology
Targets	Antibiotic

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