IWP 2
| CAS No. | 686770-61-6 | Cat. No. | BCP09534 |
| Name | IWP 2 | ||
| Synonyms | IWP-2;IWP2; | ||
| Formula | C22H18N4O2S3 | M. Wt | 466.6 |
| Description | in vitro: Inhibition of WNT signalling using FH535 and IWP-2 brought about a significant or borderline significant decrease in Caco-2(WISP2 KO) cell invasion (FH535 p=0.065) and (IWP-2 p=0.002) and negated the pro-invasive effect of targeting WISP2 in Caco-2 cells . IWP-2 decreased MKN28 cell proliferation, migration and invasion, and elevated caspase 3/7 activity. Further analysis demonstrated that IWP-2 downregulated the transcriptional activity of the Wnt/β-catenin signaling pathway and downregulated the expression levels of downstream Wnt/β-catenin target genes in MKN28 cells. Suppression of Wnt secretion from MSCs (IWP-2; 5 μmol/l) reduced the efficacy of ConT to induce phospho-LRP6 and to increase θ. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Wnt | ||
Structure
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