西司他丁钠

  • 化学数据
CAS号 81129-83-1 货号 BCP09574
中文名 西司他丁钠
英文名 Cilastatin sodium
中文别名
英文别名 Cilastatin; Cilastatine; Cilastatinum; MK 0791; MK 791; M K-791; MK0791; MK791;
分子式 C16H24N2Na2O5S 分子量 402.42
  • 用途
生物活性 Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta-lactamase that usually confer antibiotic resistance to certain bacteria.
信号通路 GPCR/G Protein 
靶 点 Leukotriene Receptor 

结构式

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