Entospletinib
CAS号 | 1229208-44-9 | 货号 | BCP09582 |
中文名 | Entospletinib | ||
英文名 | Entospletinib | ||
中文别名 | |||
英文别名 | GS-9973; GS 9973;GS9973; | ||
分子式 | C23H21N7O | 分子量 | 411.46 |
生物活性 | Entospletinib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity. Upon oral administration of entospletinib, this agent may inhibit the activity of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition of tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoeitic malignancies. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | Syk |
结构式
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