Loxistatin
| CAS No. | 88321-09-9 | Cat. No. | BCP20521 |
| Name | Loxistatin | ||
| Synonyms | EP453;E-64D;E-64-d;E-64c ethyl ester; Aloxistatin;NSC 694281; NSC694281; NSC-694281;EP-453; EP 453; | ||
| Formula | C17H30N2O5 | M. Wt | 342.43 |
| Description | Aloxistatin (E-64d), is a selective cysteine protease inhibitor or calpain and autophagy inhibitor. E-64d prevents in vitro cerulein- induced trypsinogen activation. E-64d can enter the intact cell and inhibit calpain. E-64d has been shown safe for the treatment of Alzheimer's disease in human. E-64d is potentially useful in the treatment of developmental seizure-induced brain damage both by regulating abnormal zinc signal transduction and through the modulation of altered lipid metabolism via ApoE/clusterin pathway in hippocampus. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Cathepsin | ||
Structure
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