Proteasome inhibitor I
| CAS No. | 158442-41-2 | Cat. No. | BCP09729 |
| Name | Proteasome inhibitor I | ||
| Synonyms | Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde; | ||
| Formula | C32H50N4O8 | M. Wt | 618.76 |
| Description | Proteasome inhibitor; inhibits chymotrypsin-like activity of the proteasome. Causes dopaminergic cell death in vitro. Prevents activation of NF-κB in response to TNF-α and okadaic acid (Cat. No. 1136) by inhibiting IκB-α degradation. Also inhibits NO production by LPS-activated macrophages. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Proteasome | ||
Structure
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