Dasatinib monohydrate
| CAS No. | 863127-77-9 | Cat. No. | BCP09727 |
| Name | Dasatinib monohydrate | ||
| Synonyms | BMS354825; BMS-354825; BMS354825; | ||
| Formula | C22H28ClN7O3S | M. Wt | 506.02 |
| Description | Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Src/Bcr Abl | ||
Structure
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