Atazanavir
| CAS No. | 198904-31-3 | Cat. No. | BCP09735 |
| Name | Atazanavir | ||
| Synonyms | BMS 232632;BMS-232632;BMS232632; | ||
| Formula | C38H52N6O7 | M. Wt | 704.87 |
| Description | Atazanavir is generally more potent than the five currently approved HIV-1 Prt inhibitors. Atazanavir inhibited the proteolytic cleavage of the viral gag precursor p55 polyprotein in a dose-dependent manner, with a EC50 of approximately 47 nM. Furthermore, Atazanavir is highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6,500- to 23,000-fold higher than that required for anti-HIV activity. Atazanavir may be an effective HIV-1 inhibitor that may be utilized in a variety of different drug combinations. | ||
| Pathways | Protease/Metabolic Enzyme Microbiology/Virology | ||
| Targets | HIV Protease HIV | ||
Structure
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