Cantharidin
| CAS No. | 56-25-7 | Cat. No. | BCP09819 |
| Name | Cantharidin | ||
| Synonyms | AI3-04021; AI304021; AI3 04021; BRN-0085302; BRN0085302; BRN 0085302; Cantharidine; Cantharone; | ||
| Formula | C10H12O4 | M. Wt | 196.2 |
| Description | Cantharidine is a PP1/2A inhibitor found in Canarthis vesicatoria. It inhibits proliferation of colorectal cancer cells, increases MCP-1, IL-6, and IL-β levels, and inhibits differentiation and resorptive activity of osteoclasts. This compound can produce severe skin inflammation, and is extremely toxic if ingested orallyNatural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid. Displays > 500-fold selectivity over PP2B. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphatase | ||
Structure
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