Phentolamine mesylate

CAS No.	65-28-1	Cat. No.	BCP09845
Name	Phentolamine mesylate
Synonyms	Regitine mesylate;Phentolamine methanesulfonate;Rogitine;Vasomax;
Formula	C18H23N3O4S	M. Wt	377.46

Description	Phentolamine Mesylate is a alpha 1- and alpha 2-blocking agent. Phentolamine leads to an increase in FBM by preferentially antagonizing presynaptic alpha 2-adrenoreceptors over postsynaptic alpha 1-adrenoreceptors. This influence of phentolamine on FBM may be secondary to its effect on ECoG. Promotion of LV-ECoG by catecholamines is mediated via an alpha 1-independent mechanism. phentolamine increased catecholamine release by presynaptic alpha 2-blockade, thereby suppressing the autoinhibition of transmitter release. This excess of catecholamines causes a rise of oxygen consumption and vasodilation by beta-adrenergic stimulation. Under beta-blockade, this excess competitively counteracts the postsynaptic vascular alpha-blockade. The combination of pre- and postsynaptic effects invalidates the use of phentolamine in the assessment of alpha-adrenoceptor-mediated vasoconstrictor tone.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	Adrenergic Receptor

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