losmapimod
| CAS No. | 585543-15-3 | Cat. No. | BCP09909 |
| Name | losmapimod | ||
| Synonyms | GW856553; GW-856553; GW 856553;GW856553X;GSK-AHAB; | ||
| Formula | C22H26FN3O2 | M. Wt | 383.2 |
| Description | Losmapimod is an orally bioavailable inhibitor of the alpha and beta isoforms of p38 mitogen-activated protein kinase (MAPK), with potential immunomodulating and anti-inflammatory activities. Upon oral administration, losmapimod inhibits the activity of p38alpha/beta MAPK, thereby preventing p38alpha/beta MAPK-mediated signaling. This may result in the inhibition of the production of proinflammatory cytokines. p38 MAPK, a serine/threonine protein kinase, plays an important role in regulating the transcription and translation of cytokines involved in inflammation including tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1, IL-6 and IL-8. | ||
| Pathways | MAPK Pathway | ||
| Targets | p38 MAPK | ||
Structure
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