SGI-1027
| CAS No. | 1020149-73-8 | Cat. No. | BCP09928 |
| Name | SGI-1027 | ||
| Synonyms | SGI 1027;SGI1027; | ||
| Formula | C27H23N7O | M. Wt | 461.52 |
| Description | SGI-1027, inhibits the activity of DNMT1, DNMT3A, and DNMT3B as well M. SssI with comparable IC(50) (6-13 micromol/L) by competing with S-adenosylmethionine in the methylation reaction. Treatment of different cancer cell lines with SGI-1027 resulted in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B. At a concentration of 2.5 to 5 micromol/L (similar to that of decitabine), complete degradation of DNMT1 protein was achieved within 24 h without significantly affecting its mRNA level. | ||
| Pathways | Epigenetics | ||
| Targets | DNA Methyltransferase | ||
Structure
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