TH-237A
| CAS No. | 935467-97-3 | Cat. No. | BCP10061 |
| Name | TH-237A | ||
| Synonyms | TH 237A;TH237A;meso-GS 164; | ||
| Formula | C18H17F2NO3 | M. Wt | 333.33 |
| Description | Primary neurons were isolated from embryonic Sprague-Dawley rats, grown in culture (Michaelis et al., 1994) and exposed to either Aβ25-35 or Aβ1-42 in the presence or absence of TH-237A at concentrations ranging from 0.5 to 60 nM. The neurons were treated with TH-237A for 2 hours prior to exposure to the Aβ peptides. Changes in neuronal survival following treatment with TH 237A were evaluated using the Live/Dead assay. The EC50 for TH-237A was 5 nM, demonstrating that it had excellent neuroprotective properties. | ||
| Pathways | Others Pathway | ||
| Targets | Others | ||
Structure
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