地拉普利

  • 化学数据
CAS号 83435-66-9 货号 BCP10257
中文名 地拉普利
英文名 Delapril
中文别名
英文别名 Alindapril;CV-3317;CV 3317;CV3317;
分子式 C26H32N2O5 分子量 452.54
  • 用途
生物活性 Delapril is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
信号通路 Protease/Metabolic Enzyme Hormone Pathay 
靶 点 RAAS/ACE 

结构式

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