Siponimod
| CAS No. | 1230487-00-9 | Cat. No. | BCP10335 |
| Name | Siponimod | ||
| Synonyms | BAF-312;BAF 312;BAF312; | ||
| Formula | C29H35F3N2O3 | M. Wt | 516.6 |
| Description | Siponimod is extensively bound to rat, dog, monkey, and human plasma proteins (>99.9%). It shows high and passive permeability in a Caco-2 human cell permeability assay with no transporter-mediated efflux observed at the test concentrations of 0.5–50 μM. Siponimod is moderately distributed to tissues as compared to total body water following intravenous administration to rat (Vss = 2.15 ± 0.31 L/kg) and monkey (Vss = 2.12 ± 0.12 L/kg). | ||
| Pathways | GPCR/G Protein | ||
| Targets | S1P Receptor | ||
Structure
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