Splitomicin
| CAS No. | 5690-03-9 | Cat. No. | BCP10432 |
| Name | Splitomicin | ||
| Synonyms | |||
| Formula | C13H10O2 | M. Wt | 198.22 |
| Description | Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | HDAC | ||
Structure
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