IDO inhibitor 1

CAS No.	1204669-37-3	Cat. No.	BCP10561
Name	IDO inhibitor 1
Synonyms	INCB024360; INCB 024360; INCB-024360; INCB24360; INCB-24360; INCB 24360; Epacadostat;
Formula	C11H13BrFN7O4S	M. Wt	438.23

Description	Epacadostat, also known as INCB024360 or INCB24360, is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase.
Pathways	Protease/Metabolic Enzyme
Targets	IDO

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