IDO inhibitor 1
| CAS号 | 1204669-37-3 | 货号 | BCP10561 |
| 中文名 | IDO inhibitor 1 | ||
| 英文名 | IDO inhibitor 1 | ||
| 中文别名 | |||
| 英文别名 | INCB024360; INCB 024360; INCB-024360; INCB24360; INCB-24360; INCB 24360; Epacadostat; | ||
| 分子式 | C11H13BrFN7O4S | 分子量 | 438.23 |
| 生物活性 | Epacadostat, also known as INCB024360 or INCB24360, is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | IDO | ||
结构式
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