PND-1186
| CAS No. | 1061353-68-1 | Cat. No. | BCP10711 |
| Name | PND-1186 | ||
| Synonyms | PND1186;PND 1186; SR 2516; SR2516; SR2516; VS4718; VS4718; VS 4718; | ||
| Formula | C25H26F3N5O3 | M. Wt | 501.5 |
| Description | PND-1186, also known as SR-2156 and VS-4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 µM PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 µM PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. PND-1186 inhibited 4T1 breast carcinoma subcutaneous tumor growth correlated with elevated tumor cell apoptosis and caspase 3 activation. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FAK | ||
Structure
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