Beclabuvir
| CAS号 | 958002-33-0 | 货号 | BCP11013 |
| 中文名 | Beclabuvir | ||
| 英文名 | Beclabuvir | ||
| 中文别名 | |||
| 英文别名 | BMS791325;BMS 791325;BMS-791325; | ||
| 分子式 | C36H45N5O5S | 分子量 | 659.84 |
| 生物活性 | Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. B | ||
| 信号通路 | Protease/Metabolic Enzyme Microbiology/Virology | ||
| 靶 点 | HCV Protease HCV | ||
结构式
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