Beclabuvir hydrochloride

CAS No.	958002-36-3	Cat. No.	BCP11012
Name	Beclabuvir hydrochloride
Synonyms	Beclabuvir HCl；BMS-791325 hydrochloride; BMS791325 HCl; BMS 791325 hydrochloride;
Formula	C36H45N5O5S.HCl	M. Wt	696.3

Description	Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. BMS-791325 was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clinical evaluation.
Pathways	Protease/Metabolic Enzyme Microbiology/Virology
Targets	HCV Protease HCV

Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.

For product details of different batches, please contact our Customer

Products are for research use only and not for human use. We do not sell to patients.