ZK 200775
| CAS No. | 161605-73-8 | Cat. No. | BCP11020 |
| Name | ZK 200775 | ||
| Synonyms | ZK-200775;ZK200775; | ||
| Formula | C14H15F3N3O6P | M. Wt | 409.25 |
| Description | In rat cortical membranes, it displays high affinity for [3H]-AMPA (Ki = 120 nM) and [3H]-CNQX (Ki = 32 nM) binding sites but low affinity for kainate and NMDA channel-associated binding sites (IC50 values range from 2.5 to 11 μM). It inhibits currents induced by AMPA, kainate and NMDA with IC50 values of 21 nM, 27 nM, and > 1 μM respectively. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | AMPA/NMDA | ||
Structure
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