Olverembatinib dimesylate
| CAS No. | 1421783-64-3 | Cat. No. | BCP11025 |
| Name | Olverembatinib dimesylate | ||
| Synonyms | GZD824 Dimesylate;GZD-824 Dimesylate;GZD 824 Dimesylate;GZD 824;GZD-824; | ||
| Formula | C29H27F3N6O.2CH4O3S | M. Wt | 724.77 |
| Description | GZD824 potently inhibits the growth of Ba/F3 cells expressing wildtype Bcr-Abl with IC50 of 1.0 nM. Highly consistent with biochemical kinase inhibition and tight protein binding affinity, GZD824 also strongly inhibits the proliferation of Ba/F3 cells expressing Bcr-AblT315I mutant and 14 other resistance-relevant Bcr-Abl mutants. In addition, GZD824 efficiently suppresses the activation of Bcr-Abl as well as downstream Crkl and STAT5 in a concentration-dependent manner in K562 CML cells. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Src/Bcr Abl | ||
Structure
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