SJB2-043
| CAS号 | 63388-44-3 | 货号 | BCP11060 |
| 中文名 | SJB2-043 | ||
| 英文名 | SJB2-043 | ||
| 中文别名 | |||
| 英文别名 | SJB2 043;SJB2043; | ||
| 分子式 | C17H9NO3 | 分子量 | 275.26 |
| 生物活性 | Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed by immunoblotting with anti-USP1 or anti-HA antibodies. Consistent with our previous studies and the most recent studies by Piatkov et al (24, 31, 33), USP1 in the untreated cells was detected on western blot as a doublet; full length USP1 and an auto-cleaved USP1 with only N-terminus. The Ub-USP1 conjugates were generated in the untreated cell lysates and were detected by an increase in molecular weight of USP1. However, the formation of the Ub-USP1 conjugate was inhibited by the addition of SJB2-043. Ub-aldehyde, a potent known nonspecific DUB inhibitor, caused a complete loss of USP1-Ub-VS conjugates in this competition assay. SJB2-043 inhibited the Ub-VS labeling of a limited number of endogenous DUB enzymes. In addition, SJB2-043 inhibited the labeling of USP1 with Ub-VS in a dose dependent manner. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DUB | ||
结构式
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