MI-3
| CAS No. | 1271738-59-0 | Cat. No. | BCP11052 |
| Name | MI-3 | ||
| Synonyms | MI3;MI 3;Menin-MLL inhibitor 3;Menin-MLL Inhibitor; | ||
| Formula | C18H25N5S2 | M. Wt | 375.55 |
| Description | MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL, as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Methyltransferase | ||
Structure
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