Hydroxyfasudil hydrochloride
| CAS No. | 155558-32-0 | Cat. No. | BCP11069 |
| Name | Hydroxyfasudil hydrochloride | ||
| Synonyms | Hydroxyfasudil HCl;HA-1100 hydrochloride;HA 1100 hydrochloride;HA1100 hydrochloride; | ||
| Formula | C14H18ClN3O3S | M. Wt | 343.83 |
| Description | Hydroxyfasudil, aslo known as HA1100, is a cell-permeable hydroxylated metabolite of HA-1077, is a potent inhibitor of Rho-associated kinase (ROCK) (Ki = 150 nM). Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model. | ||
| Pathways | Cell Cycle/DNA Damage TGF beta/Smad Wnt/Stem Cell | ||
| Targets | ROCK | ||
Structure
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