AVE 0991 sodium salt
| CAS No. | 306288-04-0 | Cat. No. | BCP11068 |
| Name | AVE 0991 sodium salt | ||
| Synonyms | AVE0991 sodium salt;AVE-0991 sodium salt; | ||
| Formula | C29H31N4NaO5S2 | M. Wt | 602.7 |
| Description | in vivo: In water-loaded C57BL/6 mice, AVE 0091 (0.58 nmol/g body weight) produced a significant reduction in urinary volume (0.06+/-0.03 mL/60 min [n=9] versus 0.27+/-0.05 [n=9]; P<0.01), associated with an increase in urinary osmolality [2]. In normal hearts, AVE-0991 produced a significant decrease in perfusion pressure and an increase in systolic tension, rate of tension rise and fall (+/-dT/dt), and heart rate. These effects were completely blocked by the perfusion of the hearts with a solution containing the selective ANG-(1-7) antagonist A-779. N(G)-nitro-l-arginine methyl ester treatment abolished the AVE-0991-induced vasodilation in isolated hearts. AVE-0991significantly attenuated the decrease in systolic tension (sham operated, 13.00 +/- 1.02 g; infarction, 7.18 +/- 0.66 g; AVE treated, 9.23 +/- 1.05 g, n = 5), +dT/dt, -dT/dt, and heart rate induced by myocardial infarction. Infarction-induced vasoconstriction was completely prevented by AVE-0991treatment. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Angiotensin Receptor | ||
Structure
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