Dovitinib Dilactic acid

CAS No.	852433-84-2	Cat. No.	BCP11139
Name	Dovitinib Dilactic acid
Synonyms	TKI258 Dilactic acid;TKI258; TKI-258; TKI 258; CHIR258; CHIR-258; CHIR 258;
Formula	C27H33FN6O7	M. Wt	572.59

Description	Dovitinib, also known as TKI-258 or CHIR-258, is an orally bioavailable FGFR3 inhibitor, which strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis.
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	PDGFR VEGFR c Kit FLT3 FGFR

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