LB-100
| CAS No. | 1026680-07-8 | Cat. No. | BCP11234 |
| Name | LB-100 | ||
| Synonyms | LB 100;LB100; | ||
| Formula | C13H20N2O4 | M. Wt | 268.31 |
| Description | LB-100 inhibits the cell growth with IC50 of 2.3 μM (in BxPc-3) or 1.7 μM (in Panc-1 cell). In BxPc-3, Panc-1, and SW1990 cells, LB-100 reduces the PP2A activity by 30-50%. LB-100 increases concentration of doxorubicin within cells (2.5 fold to control) and sensitizes tumor cells to the cytotoxicity of doxorubicin. LB-100 increaseds VEGF secretion, and thus enhances HIF-1α-VEGF mediated angiogenesis. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphatase | ||
Structure
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