9-Hydroxyellipticine Hydrochloride

CAS No.	52238-35-4	Cat. No.	BCP11301
Name	9-Hydroxyellipticine Hydrochloride
Synonyms	Ellipticine Analog;9-hydroxyellipticine hydrochloride; Hydroxyellipticine; 9-Hydroxyellipticin; NSC 210717; IGIG 929; IGIG929; IGIG-929; LS133324; LS-133324; LS 133324;
Formula	C17H15ClN2O	M. Wt	298.77

Description	9-hydroxyellipticine, also known as IGIG 929 and LS133324, is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines.
Pathways	Cell Cycle/DNA Damage
Targets	Topoisomerase

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