ARQ 621
| CAS No. | 1095253-39-6 | Cat. No. | BCP28395 |
| Name | ARQ 621 | ||
| Synonyms | ARQ621; ARQ-621; | ||
| Formula | C28H24Cl2FN5O2 | M. Wt | 552.43 |
| Description | ARQ-621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target. Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Kinesin | ||
Structure
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