BMN-673 8R,9S

CAS No.	1207456-00-5	Cat. No.	BCP11682
Name	BMN-673 8R,9S
Synonyms	(8R,9S)-BMN-673;BMN673 (8R,9S);BMN 673 (8R,9S);Talazoparib (8R,9S);
Formula	C19H14F2N6O	M. Wt	380.35

Description	BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.
Pathways	Cell Cycle/DNA Damage Epigenetics
Targets	PARP

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