Nifuroxazide

CAS No.	965-52-6	Cat. No.	BCP11876
Name	Nifuroxazide
Synonyms	Nifuroxazid; Diafuryl; Diarlidan;
Formula	C12H9N3O5	M. Wt	275.22

Description	Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation. Nifuroxazide inhibits the constitutive phosphorylation of STAT3 in MM cells by reducing Jak kinase autophosphorylation, and leads to down-regulation of the STAT3 target gene Mcl-1.
Pathways	Jak/Stat Pathway Wnt/Stem Cell
Targets	Stat

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