Meprednisone
| CAS No. | 1247-42-3 | Cat. No. | BCP11933 |
| Name | Meprednisone | ||
| Synonyms | Betanisona;Betapar; | ||
| Formula | C22H28O5 | M. Wt | 372.46 |
| Description | Meprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Glucocorticoid Receptor | ||
Structure
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