Paroxetine hydrochloride hemihydrate

CAS No.	110429-35-1	Cat. No.	BCP11973
Name	Paroxetine hydrochloride hemihydrate
Synonyms	BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate;
Formula	C19H20FNO3.HCl.1/2H2O	M. Wt	374.83

Description	Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression. It is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors.
Pathways	Neuro Signaling Pathway
Targets	SSRI

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