沙库必曲
| CAS号 | 149709-62-6 | 货号 | BCP11975 |
| 中文名 | 沙库必曲 | ||
| 英文名 | Sacubitril | ||
| 中文别名 | 沙库巴曲; | ||
| 英文别名 | AHU-377;AHU377;AHU 377; | ||
| 分子式 | C24H29NO5 | 分子量 | 411.49 |
| 生物活性 | Sacubitril, also known as AHU377, is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Neprilysin | ||
结构式
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