奥扎格雷
| CAS号 | 82571-53-7 | 货号 | BCP12147 |
| 中文名 | 奥扎格雷 | ||
| 英文名 | Ozagrel | ||
| 中文别名 | |||
| 英文别名 | OKY046;OKY-046;OKY 046; | ||
| 分子式 | C13H12N2O2 | 分子量 | 228.25 |
| 生物活性 | Ozagrel was selected as the best compound of highly selective inhibitors of TXA2 synthase. The inhibition of TXA2 synthase by ozagrel was more effective on human and rabbit enzymes than those of other species. Ozagrel increased 6-keto-PGF1 alpha, one of stable metabolites of PGI2, in various isolated cells and tissues perhaps via accumulated PG endoperoxides resulted by the inhibition of TXA2 synthase . Ozagrel was estimated to be a reversible mixed-type inhibitor of diphenolase activity with the constants (K (S1), K (S2), K (i1), and K (i2)) determined to be 2.21, 3.89, 0.454, and 0.799 mM, repectively . Infusion of OKY-046 significantly inhibited pulmonary thromboxane B2 delivery, attenuated the early increase in pulmonary vascular resistance, and blocked the increase in systemic vascular resistance. In addition, OKY-046 blunted and delayed the decrease in cardiac output and maintained end-systolic pressure-diameter relation, +dp/dt, and lung lymph flow at baseline values . | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Factor Xa | ||
结构式
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