Ethambutol dihydrochloride

CAS No.	1070-11-7	Cat. No.	BCP12151
Name	Ethambutol dihydrochloride
Synonyms	Myambutol dihydrochloride;Emb dihydrochloride;
Formula	C10H24N2O2.2ClH	M. Wt	277.23

Description	Ethambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants . Ethambutol is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. Ethambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro . Ethambutol is efficient on treatment of mycobacterial-infected macrophages.
Pathways	Microbiology/Virology
Targets	Antibiotic

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